SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03044

Signal sequence   MMWPMHTPLLLLTALMVAVA

Length  20

Organism  Homo sapiens (Human)

UniProt ID  P28325,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03044.cif

Structure  SPKB03044.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2239.88214

Aliphatic index  141.5

Isoelectric point  7.550323994

Charge (pH=7)   0.08889339

Topological polar surface area  683.57

Aromaticity  0.05

Average rotatable bonds  3.35

Number of hydrogen bond donors  23

Number of hydrogen bond acceptors  28

X logP energy  0.6879

Hydropathy 



Literature Information


Title  Structural and functional characterization of two allelic variants of human cystatin D sharing a characteristic inhibition spectrum against mammalian cysteine proteinases.

DOI  NA,

Publication Year  1994

PubMed ID  8083219,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.