SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03019

Signal sequence   MVGSYVLWLALASCILTLASP

Length  21

Organism  Canis lupus familiaris (Dog) (Canis familiaris)

UniProt ID  P25291,

Motif  1..21



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03019.cif

Structure  SPKB03019.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2208.70214

Aliphatic index  153.3333333

Isoelectric point  5.919503212

Charge (pH=7)   -0.064840831

Topological polar surface area  753.47

Aromaticity  0.095238095

Average rotatable bonds  3.142857143

Number of hydrogen bond donors  28

Number of hydrogen bond acceptors  29

X logP energy  -3.4069

Hydropathy 



Literature Information


Title  A single gene encodes membrane-bound and free forms of GP-2, the major glycoprotein in pancreatic secretory (zymogen) granule membranes.

DOI  10.1073/pnas.88.7.2898,

Publication Year  1991

PubMed ID  2011597,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.