SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03017

Signal sequence   MGPRRLLLVAACFSLCGPLLS

Length  21

Organism  Homo sapiens (Human)

UniProt ID  P25116,

Motif  1..21



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03017.cif

Structure  SPKB03017.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2217.77724

Aliphatic index  134.7619048

Isoelectric point  8.834915637

Charge (pH=7)   1.874028245

Topological polar surface area  792

Aromaticity  0.047619048

Average rotatable bonds  3.285714286

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  29

X logP energy  -5.29156

Hydropathy 



Literature Information


Title  The protease-activated receptor 1 possesses a functional and cleavable signal peptide which is necessary for receptor expression.

DOI  10.1016/j.febslet.2012.05.042,

Publication Year  2012

PubMed ID  22659187,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.