SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB03004

Signal sequence   MKSLVLLLCFAQLWSCQS

Length  18

Organism  Rattus norvegicus (Rat)

UniProt ID  P24090,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB03004.cif

Structure  SPKB03004.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2070.55374

Aliphatic index  130

Isoelectric point  8.229691165

Charge (pH=7)   0.873739834

Topological polar surface area  746.7

Aromaticity  0.111111111

Average rotatable bonds  3.777777778

Number of hydrogen bond donors  28

Number of hydrogen bond acceptors  28

X logP energy  -4.2374

Hydropathy 



Literature Information


Title  Purification, characterization, and studies on biosynthesis of a 59-kDa bone sialic acid-containing protein (BSP) from rat mandible using a monoclonal antibody. Evidence that 59-kDa BSP may be the rat counterpart of human alpha 2-HS glycoprotein and is synthesized by both hepatocytes and osteoblasts.

DOI  NA,

Publication Year  1991

PubMed ID  1860865,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.