SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02993

Signal sequence   MISVGEIMERANHSLVRMRR

Length  20

Organism  Latrodectus tredecimguttatus (Mediterranean black widow spider) (Latrodectus mactans tredecimguttatus)

UniProt ID  P23631,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  9GO9,

Predicted Structure ID  SPKB02993.cif

Structure  SPKB02993.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2385.84944

Aliphatic index  92.5

Isoelectric point  12.02309898

Charge (pH=7)   2.092430391

Topological polar surface area  1050.65

Aromaticity  0

Average rotatable bonds  4.2

Number of hydrogen bond donors  39

Number of hydrogen bond acceptors  34

X logP energy  -10.42112

Hydropathy 



Literature Information


Title  Black widow spider toxins: the present and the future.

DOI  10.1016/s0041-0101(98)00162-7,

Publication Year  1998

PubMed ID  9792186,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.