SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02981

Signal sequence   MRMLLALLALSAARPSAS

Length  18

Organism  Homo sapiens (Human)

UniProt ID  P22748,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02981.cif

Structure  SPKB02981.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1872.31774

Aliphatic index  136.1111111

Isoelectric point  12.50010931

Charge (pH=7)   1.997977677

Topological polar surface area  733.72

Aromaticity  0

Average rotatable bonds  3.388888889

Number of hydrogen bond donors  27

Number of hydrogen bond acceptors  26

X logP energy  -6.51426

Hydropathy 



Literature Information


Title  Carbonic anhydrase IV from human lung. Purification, characterization, and comparison with membrane carbonic anhydrase from human kidney.

DOI  NA,

Publication Year  1990

PubMed ID  2111324,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.