SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02977

Signal sequence   MAPLRPIFTLALLLWVVLA

Length  19

Organism  Oryctolagus cuniculus (Rabbit)

UniProt ID  P22458,

Motif  1..19



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02977.cif

Structure  SPKB02977.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2137.74104

Aliphatic index  190

Isoelectric point  10.55000222

Charge (pH=7)   0.997980988

Topological polar surface area  667.46

Aromaticity  0.105263158

Average rotatable bonds  3.315789474

Number of hydrogen bond donors  23

Number of hydrogen bond acceptors  23

X logP energy  2.19537

Hydropathy 



Literature Information


Title  Vitronectin diversity in evolution but uniformity in ligand binding and size of the core polypeptide.

DOI  10.1016/0167-4838(92)90417-c,

Publication Year  1992

PubMed ID  1372829,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.