SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02959

Signal sequence   MPEFLTVVSWPFLILLSFQVRVVAG

Length  25

Organism  Rattus norvegicus (Rat)

UniProt ID  P21743,

Motif  1..25



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02959.cif

Structure  SPKB02959.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2849.47014

Aliphatic index  140

Isoelectric point  6.410149741

Charge (pH=7)   -0.000243889

Topological polar surface area  962.91

Aromaticity  0.16

Average rotatable bonds  3.44

Number of hydrogen bond donors  33

Number of hydrogen bond acceptors  33

X logP energy  -1.82813

Hydropathy 



Literature Information


Title  Production of the rat type 1 insulin-like growth factor-binding protein by well differentiated H4EIIC3 hepatoma cells: identification, purification, and N-terminal amino acid analysis.

DOI  10.1210/endo-127-2-789,

Publication Year  1990

PubMed ID  2164920,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.