SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02956

Signal sequence   MCPRAARAPATLLLALGAVLWPAAGA

Length  26

Organism  Homo sapiens (Human)

UniProt ID  P21589,

Motif  1..26



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  7QGM,

Predicted Structure ID  SPKB02956.cif

Structure  SPKB02956.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2562.13264

Aliphatic index  120.7692308

Isoelectric point  10.52640717

Charge (pH=7)   1.936002961

Topological polar surface area  924.27

Aromaticity  0.038461538

Average rotatable bonds  2.846153846

Number of hydrogen bond donors  33

Number of hydrogen bond acceptors  32

X logP energy  -6.32046

Hydropathy 



Literature Information


Title  Characterization of soluble vs membrane-bound human placental 5'-nucleotidase.

DOI  10.1016/0006-291x(90)91601-n,

Publication Year  1990

PubMed ID  2173922,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.