SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02948

Signal sequence   MRACISLVLAVLCGLAWA

Length  18

Organism  Homo sapiens (Human)

UniProt ID  P21128,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  9FTW,

Predicted Structure ID  SPKB02948.cif

Structure  SPKB02948.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1890.39364

Aliphatic index  162.7777778

Isoelectric point  8.231408964

Charge (pH=7)   0.874031556

Topological polar surface area  655.94

Aromaticity  0.055555556

Average rotatable bonds  3.277777778

Number of hydrogen bond donors  26

Number of hydrogen bond acceptors  24

X logP energy  -2.51433

Hydropathy 



Literature Information


Title  Cloning and expression of a cDNA encoding human placental protein 11, a putative serine protease with diagnostic significance as a tumor marker.

DOI  10.1089/dna.1990.9.243,

Publication Year  1990

PubMed ID  2350438,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.