SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02946

Signal sequence   MARKSNLPVLLVPFLLCQALVRC

Length  23

Organism  Homo sapiens (Human)

UniProt ID  P20933,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02946.cif

Structure  SPKB02946.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2585.26904

Aliphatic index  148.2608696

Isoelectric point  9.914555929

Charge (pH=7)   2.873733211

Topological polar surface area  942.17

Aromaticity  0.043478261

Average rotatable bonds  3.608695652

Number of hydrogen bond donors  34

Number of hydrogen bond acceptors  33

X logP energy  -4.99516

Hydropathy 



Literature Information


Title  Aspartylglycosaminuria in the Finnish population: identification of two point mutations in the heavy chain of glycoasparaginase.

DOI  10.1073/pnas.88.7.2941,

Publication Year  1991

PubMed ID  2011603,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.