SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02937

Signal sequence   MAPVAVWAALAVGLELWAAAHA

Length  22

Organism  Homo sapiens (Human)

UniProt ID  P20333,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02937.cif

Structure  SPKB02937.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2218.64464

Aliphatic index  133.6363636

Isoelectric point  5.363507222

Charge (pH=7)   -0.909331487

Topological polar surface area  763.19

Aromaticity  0.090909091

Average rotatable bonds  2.863636364

Number of hydrogen bond donors  26

Number of hydrogen bond acceptors  26

X logP energy  -1.9662

Hydropathy 



Literature Information


Title  Purification and partial amino acid sequence analysis of two distinct tumor necrosis factor receptors from HL60 cells.

DOI  NA,

Publication Year  1990

PubMed ID  2173696,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.