SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02930

Signal sequence   MRHLGAFLFLLGVLGALT

Length  18

Organism  Homo sapiens (Human)

UniProt ID  P20062,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02930.cif

Structure  SPKB02930.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1929.39704

Aliphatic index  157.2222222

Isoelectric point  10.5517587

Charge (pH=7)   1.088890079

Topological polar surface area  668.83

Aromaticity  0.111111111

Average rotatable bonds  3.444444444

Number of hydrogen bond donors  24

Number of hydrogen bond acceptors  23

X logP energy  -1.64513

Hydropathy 



Literature Information


Title  Purification and molecular characterization of human transcobalamin II.

DOI  NA,

Publication Year  1986

PubMed ID  3782074,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.