SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02922

Signal sequence   MNSKLAVALLATFLLSLTLCEA

Length  22

Organism  Oryctolagus cuniculus (Rabbit)

UniProt ID  P19874,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02922.cif

Structure  SPKB02922.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2322.84684

Aliphatic index  155.4545455

Isoelectric point  6.231833229

Charge (pH=7)   -0.062510328

Topological polar surface area  861.75

Aromaticity  0.045454545

Average rotatable bonds  3.5

Number of hydrogen bond donors  31

Number of hydrogen bond acceptors  32

X logP energy  -5.8216

Hydropathy 



Literature Information


Title  A novel neutrophil chemoattractant generated during an inflammatory reaction in the rabbit peritoneal cavity in vivo. Purification, partial amino acid sequence and structural relationship to interleukin 8.

DOI  10.1042/bj2710797,

Publication Year  1990

PubMed ID  2244880,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.