SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02912

Signal sequence   MAYLLHAQLFLLTTFILVLNMRLCPVL

Length  27

Organism  Rattus norvegicus (Rat)

UniProt ID  P19313,

Motif  1..27



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02912.cif

Structure  SPKB02912.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3147.97524

Aliphatic index  173.3333333

Isoelectric point  8.534796248

Charge (pH=7)   1.026064949

Topological polar surface area  1048.58

Aromaticity  0.111111111

Average rotatable bonds  3.703703704

Number of hydrogen bond donors  37

Number of hydrogen bond acceptors  38

X logP energy  -0.67663

Hydropathy 



Literature Information


Title  Amino acid sequence of an inducible cysteine proteinase inhibitor (cystatin) from submandibular glands of isoproterenol-treated rats.

DOI  10.1016/0003-9861(89)90185-9,

Publication Year  1989

PubMed ID  2757396,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.