SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02837

Signal sequence   MKVLAAGVVPLLLVLHWKHGAG

Length  22

Organism  Homo sapiens (Human)

UniProt ID  P15018,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02837.cif

Structure  SPKB02837.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2309.88764

Aliphatic index  155

Isoelectric point  10.80546448

Charge (pH=7)   2.179212414

Topological polar surface area  790.82

Aromaticity  0.045454545

Average rotatable bonds  3.318181818

Number of hydrogen bond donors  27

Number of hydrogen bond acceptors  28

X logP energy  -1.4396

Hydropathy 



Literature Information


Title  Purification of a lipoprotein lipase-inhibiting protein produced by a melanoma cell line associated with cancer cachexia.

DOI  10.1016/s0006-291x(89)80114-7,

Publication Year  1989

PubMed ID  2730639,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.