SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02821

Signal sequence   MWVTKLLPALLLQHVLLHLLLLPIAIPYAEG

Length  31

Organism  Homo sapiens (Human)

UniProt ID  P14210,

Motif  1..31



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  7MO7,

Predicted Structure ID  SPKB02821.cif

Structure  SPKB02821.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3490.38044

Aliphatic index  191.9354839

Isoelectric point  7.704942645

Charge (pH=7)   0.180432156

Topological polar surface area  1129.97

Aromaticity  0.064516129

Average rotatable bonds  3.483870968

Number of hydrogen bond donors  37

Number of hydrogen bond acceptors  40

X logP energy  2.0604

Hydropathy 



Literature Information


Title  Identification of the N-terminal residue of the heavy chain of both native and recombinant human hepatocyte growth factor.

DOI  10.1016/0006-291x(91)91616-k,

Publication Year  1991

PubMed ID  1826837,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.