SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02815

Signal sequence   MKLPLLLALLFGAVSA

Length  16

Organism  Homo sapiens (Human)

UniProt ID  P13727,

Motif  1..16



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02815.cif

Structure  SPKB02815.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1657.13074

Aliphatic index  183.125

Isoelectric point  9.700002532

Charge (pH=7)   0.997689266

Topological polar surface area  537.28

Aromaticity  0.0625

Average rotatable bonds  3.3125

Number of hydrogen bond donors  18

Number of hydrogen bond acceptors  20

X logP energy  -0.0827

Hydropathy 



Literature Information


Title  Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma.

DOI  10.1074/jbc.270.23.13645,

Publication Year  1995

PubMed ID  7539791,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.