SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02801

Signal sequence   MKILSVLLLALIICSIVGWSEA

Length  22

Organism  Leiurus hebraeus (Hebrew deathstalker scorpion) (Leiurus quinquestriatus hebraeus)

UniProt ID  P13487,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02801.cif

Structure  SPKB02801.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2372.99334

Aliphatic index  195

Isoelectric point  6.231833229

Charge (pH=7)   -0.062510328

Topological polar surface area  814.22

Aromaticity  0.045454545

Average rotatable bonds  3.590909091

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  30

X logP energy  -1.6452

Hydropathy 



Literature Information


Title  Purification, sequence, and model structure of charybdotoxin, a potent selective inhibitor of calcium-activated potassium channels.

DOI  10.1073/pnas.85.10.3329,

Publication Year  1988

PubMed ID  2453055,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.