SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02788

Signal sequence   MGAASGRRGPGLLLPLPLLLLLPPQPALA

Length  29

Organism  Homo sapiens (Human)

UniProt ID  P12821,

Motif  1..29



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  9CLX,

Predicted Structure ID  SPKB02788.cif

Structure  SPKB02788.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2903.60874

Aliphatic index  148.2758621

Isoelectric point  12.50010931

Charge (pH=7)   1.997977677

Topological polar surface area  1012.5

Aromaticity  0

Average rotatable bonds  2.965517241

Number of hydrogen bond donors  32

Number of hydrogen bond acceptors  35

X logP energy  -5.38646

Hydropathy 



Literature Information


Title  Purification of human lung angiotensin-converting enzyme by high-performance liquid chromatography: properties and N-terminal amino acid sequence.

DOI  10.1093/oxfordjournals.jbchem.a122871,

Publication Year  1989

PubMed ID  2558109,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.