SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02777

Signal sequence   MAPAMESPTLLCVALLFFAPDGVLA

Length  25

Organism  Homo sapiens (Human)

UniProt ID  P12319,

Motif  1..25



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  8K7R,

Predicted Structure ID  SPKB02777.cif

Structure  SPKB02777.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2578.13804

Aliphatic index  121.2

Isoelectric point  3.550065871

Charge (pH=7)   -2.06176881

Topological polar surface area  850.41

Aromaticity  0.08

Average rotatable bonds  3.04

Number of hydrogen bond donors  28

Number of hydrogen bond acceptors  33

X logP energy  -3.5405

Hydropathy 



Literature Information


Title  High-level expression of the truncated alpha chain of human high-affinity receptor for IgE as a soluble form by baculovirus-infected insect cells. Biochemical characterization of the recombinant product.

DOI  10.1111/j.1432-1033.1994.tb18660.x,

Publication Year  1994

PubMed ID  8125119,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.