SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02776

Signal sequence   MTMETQMSQNVCPRNLWLLQPLTVLLLLASADS

Length  33

Organism  Homo sapiens (Human)

UniProt ID  P12318,

Motif  1..33



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  8CHA,

Predicted Structure ID  SPKB02776.cif

Structure  SPKB02776.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3718.41764

Aliphatic index  118.1818182

Isoelectric point  4.184374695

Charge (pH=7)   -1.061772121

Topological polar surface area  1466.06

Aromaticity  0.03030303

Average rotatable bonds  3.666666667

Number of hydrogen bond donors  50

Number of hydrogen bond acceptors  52

X logP energy  -13.17263

Hydropathy 



Literature Information


Title  Biochemical analysis and crystallisation of Fc gamma RIIa, the low affinity receptor for IgG.

DOI  10.1016/s0165-2478(99)00025-5,

Publication Year  1999

PubMed ID  10397151,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.