SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02766

Signal sequence   MGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQA

Length  40

Organism  Homo sapiens (Human)

UniProt ID  P11717,

Motif  1..40



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02766.cif

Structure  SPKB02766.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  4057.81944

Aliphatic index  115

Isoelectric point  12.97714575

Charge (pH=7)   4.088880145

Topological polar surface area  1640.74

Aromaticity  0

Average rotatable bonds  3.175

Number of hydrogen bond donors  56

Number of hydrogen bond acceptors  54

X logP energy  -17.48162

Hydropathy 



Literature Information


Title  Insulin-like growth factor II receptor as a multifunctional binding protein.

DOI  10.1038/329301a0,

Publication Year  1987

PubMed ID  2957598,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.