SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02759

Signal sequence   MAAPGSARRPLLLLLLLLLLGLMHCASA

Length  28

Organism  Homo sapiens (Human)

UniProt ID  P11279,

Motif  1..28



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  8FY5,

Predicted Structure ID  SPKB02759.cif

Structure  SPKB02759.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2915.69634

Aliphatic index  171.0714286

Isoelectric point  10.5273869

Charge (pH=7)   2.026912052

Topological polar surface area  1024.38

Aromaticity  0

Average rotatable bonds  3.357142857

Number of hydrogen bond donors  37

Number of hydrogen bond acceptors  37

X logP energy  -4.71736

Hydropathy 



Literature Information


Title  Purification and characterization of human lysosomal membrane glycoproteins.

DOI  10.1016/0003-9861(89)90597-3,

Publication Year  1989

PubMed ID  2912382,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.