SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02751

Signal sequence   MMKTLLLFVGLLLTWESGQVLG

Length  22

Organism  Homo sapiens (Human)

UniProt ID  P10909,

Motif  1..22



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02751.cif

Structure  SPKB02751.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2450.03564

Aliphatic index  150.4545455

Isoelectric point  6.408795646

Charge (pH=7)   -0.000535612

Topological polar surface area  857.31

Aromaticity  0.090909091

Average rotatable bonds  3.727272727

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  31

X logP energy  -2.4059

Hydropathy 



Literature Information


Title  Characterization of a human high density lipoprotein-associated protein, NA1/NA2. Identity with SP-40,40, an inhibitor of complement-mediated cytolysis.

DOI  10.1161/01.atv.11.3.645,

Publication Year  1991

PubMed ID  1903064,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.