SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02743

Signal sequence   MSSAARSRLTRATRQEMLFLALLLLPVVVA

Length  30

Organism  Homo sapiens (Human)

UniProt ID  P10720,

Motif  1..30



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02743.cif

Structure  SPKB02743.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3315.04234

Aliphatic index  136.6666667

Isoelectric point  12.50005466

Charge (pH=7)   2.999746177

Topological polar surface area  1327.57

Aromaticity  0.033333333

Average rotatable bonds  3.666666667

Number of hydrogen bond donors  49

Number of hydrogen bond acceptors  44

X logP energy  -10.97532

Hydropathy 



Literature Information


Title  Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis.

DOI  10.1161/01.RES.0000146674.38319.07,

Publication Year  2004

PubMed ID  15459074,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.