SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02741

Signal sequence   MIYTMKKVHALWASVCLLLNLAPAPLNA

Length  28

Organism  Homo sapiens (Human)

UniProt ID  P10646,

Motif  1..28



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  7V1N,

Predicted Structure ID  SPKB02741.cif

Structure  SPKB02741.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3082.81704

Aliphatic index  136.0714286

Isoelectric point  9.407025159

Charge (pH=7)   2.025478192

Topological polar surface area  1074.82

Aromaticity  0.071428571

Average rotatable bonds  3.428571429

Number of hydrogen bond donors  37

Number of hydrogen bond acceptors  40

X logP energy  -4.3095

Hydropathy 



Literature Information


Title  Signal peptide prediction based on analysis of experimentally verified cleavage sites.

DOI  10.1110/ps.04682504,

Publication Year  2004

PubMed ID  15340161,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.