SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02740

Signal sequence   MRSAAVLALLLCAGQVTA

Length  18

Organism  Homo sapiens (Human)

UniProt ID  P10645,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02740.cif

Structure  SPKB02740.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1788.19684

Aliphatic index  146.6666667

Isoelectric point  8.549912035

Charge (pH=7)   0.936006272

Topological polar surface area  703.47

Aromaticity  0

Average rotatable bonds  3.222222222

Number of hydrogen bond donors  26

Number of hydrogen bond acceptors  25

X logP energy  -6.54803

Hydropathy 



Literature Information


Title  The spectrum of endogenous human chromogranin A-derived peptides identified using a modified proteomic strategy.

DOI  10.1002/1615-9861(200211)2:11<1586::AID-PROT1586>3.0.CO;2-K,

Publication Year  2002

PubMed ID  12442257,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.