SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02735

Signal sequence   MRSSAALALLLCAGQVFA

Length  18

Organism  Rattus norvegicus (Rat)

UniProt ID  P10354,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02735.cif

Structure  SPKB02735.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1822.21394

Aliphatic index  130.5555556

Isoelectric point  8.549912035

Charge (pH=7)   0.936006272

Topological polar surface area  703.47

Aromaticity  0.055555556

Average rotatable bonds  3.277777778

Number of hydrogen bond donors  26

Number of hydrogen bond acceptors  25

X logP energy  -6.34983

Hydropathy 



Literature Information


Title  beta-Granins: 21 kDa co-secreted peptides of the insulin granule closely related to adrenal medullary chromogranin A.

DOI  10.1016/0014-5793(85)80398-7,

Publication Year  1985

PubMed ID  3896848,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.