SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02730

Signal sequence   MQVSTAALAVLLCTMALCNQFSA

Length  23

Organism  Homo sapiens (Human)

UniProt ID  P10147,

Motif  1..23



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02730.cif

Structure  SPKB02730.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2386.88324

Aliphatic index  114.7826087

Isoelectric point  5.826007312

Charge (pH=7)   -0.125965132

Topological polar surface area  913.71

Aromaticity  0.043478261

Average rotatable bonds  3.347826087

Number of hydrogen bond donors  33

Number of hydrogen bond acceptors  35

X logP energy  -9.5791

Hydropathy 



Literature Information


Title  BB-10010: an active variant of human macrophage inflammatory protein-1 alpha with improved pharmaceutical properties.

DOI  NA,

Publication Year  1995

PubMed ID  8541527,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.