SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02729

Signal sequence   MTSKLAVALLAAFLISAALC

Length  20

Organism  Homo sapiens (Human)

UniProt ID  P10145,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02729.cif

Structure  SPKB02729.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2007.52064

Aliphatic index  161.5

Isoelectric point  8.545189979

Charge (pH=7)   0.93571455

Topological polar surface area  702.93

Aromaticity  0.05

Average rotatable bonds  3.25

Number of hydrogen bond donors  26

Number of hydrogen bond acceptors  27

X logP energy  -3.9185

Hydropathy 



Literature Information


Title  The neutrophil-activating proteins interleukin 8 and beta-thromboglobulin: in vitro and in vivo comparison of NH2-terminally processed forms.

DOI  10.1002/eji.1830200933,

Publication Year  1990

PubMed ID  2145175,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.