SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02722

Signal sequence   MFVFLVLLPLVSS

Length  13

Organism  Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)

UniProt ID  P0DTC2,

Motif  1..13



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02722.cif

Structure  SPKB02722.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1464.86954

Aliphatic index  186.9230769

Isoelectric point  6.099999998

Charge (pH=7)   -0.002015701

Topological polar surface area  444.19

Aromaticity  0.153846154

Average rotatable bonds  3.384615385

Number of hydrogen bond donors  15

Number of hydrogen bond acceptors  17

X logP energy  1.0976

Hydropathy 



Literature Information


Title  SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern.

DOI  10.1126/science.abi7994,

Publication Year  2021

PubMed ID  34210893,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.