SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02716

Signal sequence   MKTLLLTLLVVTIVCLDLGYS

Length  21

Organism  Dendroaspis polylepis polylepis (Black mamba)

UniProt ID  P0DKR6,

Motif  1..21



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02716.cif

Structure  SPKB02716.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2308.90374

Aliphatic index  190

Isoelectric point  6.157533513

Charge (pH=7)   -0.06468938

Topological polar surface area  809.79

Aromaticity  0.047619048

Average rotatable bonds  3.619047619

Number of hydrogen bond donors  30

Number of hydrogen bond acceptors  31

X logP energy  -2.5679

Hydropathy 



Literature Information


Title  Black mamba venom peptides target acid-sensing ion channels to abolish pain.

DOI  10.1038/nature11494,

Publication Year  2012

PubMed ID  23034652,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.