SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02689

Signal sequence   MFKSTLAAMAAVFALSALSPAAMA

Length  24

Organism  Escherichia coli (strain K12)

UniProt ID  P0AFL3,

Motif  1..24



Activity Information


Pathway  Sec

Natural/Artificial  Natural

Subcellular location  Periplasmic space

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  8XCK,

Predicted Structure ID  SPKB02689.cif

Structure  SPKB02689.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2371.89674

Aliphatic index  98.33333333

Isoelectric point  9.700002532

Charge (pH=7)   0.997689266

Topological polar surface area  830.77

Aromaticity  0.083333333

Average rotatable bonds  3.083333333

Number of hydrogen bond donors  29

Number of hydrogen bond acceptors  33

X logP energy  -6.7403

Hydropathy 



Literature Information


Title  Peptidyl-prolyl cis-trans-isomerase from Escherichia coli: a periplasmic homolog of cyclophilin that is not inhibited by cyclosporin A.

DOI  10.1073/pnas.87.11.4028,

Publication Year  1990

PubMed ID  2190212,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.