SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02659

Signal sequence   MWCIVLFSLLAWVYA

Length  15

Organism  Homo sapiens (Human)

UniProt ID  P09871,

Motif  1..15



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02659.cif

Structure  SPKB02659.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1815.26424

Aliphatic index  156

Isoelectric point  5.919503212

Charge (pH=7)   -0.064840831

Topological polar surface area  542.76

Aromaticity  0.266666667

Average rotatable bonds  3.466666667

Number of hydrogen bond donors  21

Number of hydrogen bond acceptors  20

X logP energy  3.0359

Hydropathy 



Literature Information


Title  Human complement component C1s. Partial sequence determination of the heavy chain and identification of the peptide bond cleaved during activation.

DOI  10.1111/j.1432-1033.1986.tb09546.x,

Publication Year  1986

PubMed ID  3007145,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.