SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02654

Signal sequence   MTAPGAAGRCPPTTWLGSLLLLVCLLASRSIT

Length  32

Organism  Homo sapiens (Human)

UniProt ID  P09603,

Motif  1..32



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02654.cif

Structure  SPKB02654.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3270.95744

Aliphatic index  119.0625

Isoelectric point  8.834915637

Charge (pH=7)   1.874028245

Topological polar surface area  1220.25

Aromaticity  0.03125

Average rotatable bonds  3.09375

Number of hydrogen bond donors  46

Number of hydrogen bond acceptors  45

X logP energy  -11.69236

Hydropathy 



Literature Information


Title  Macrophage colony-stimulating factor purified from normal human urine. Amino-terminal sequence and amino acid composition.

DOI  10.1016/0014-5793(87)80398-8,

Publication Year  1987

PubMed ID  3498652,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.