SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02646

Signal sequence   MARAALSAAPSNPRLLRVALLLLLLVAAGRRAAG

Length  34

Organism  Homo sapiens (Human)

UniProt ID  P09341,

Motif  1..34



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02646.cif

Structure  SPKB02646.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3454.23054

Aliphatic index  149.7058824

Isoelectric point  13.10207708

Charge (pH=7)   4.997967743

Topological polar surface area  1399.09

Aromaticity  0

Average rotatable bonds  3.294117647

Number of hydrogen bond donors  51

Number of hydrogen bond acceptors  44

X logP energy  -12.47275

Hydropathy 



Literature Information


Title  Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms.

DOI  10.1046/j.1432-1327.1999.00166.x,

Publication Year  1999

PubMed ID  10095777,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.