SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02635

Signal sequence   MRALWIVAVLLVGVEGSLVEFETLMMKIAGRSGISYY

Length  37

Organism  Crotalus durissus terrificus (South American rattlesnake)

UniProt ID  P08878,

Motif  1..37



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02635.cif

Structure  SPKB02635.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  4103.95234

Aliphatic index  131.6216216

Isoelectric point  6.597033742

Charge (pH=7)   0.001307183

Topological polar surface area  1509.81

Aromaticity  0.108108108

Average rotatable bonds  3.675675676

Number of hydrogen bond donors  55

Number of hydrogen bond acceptors  53

X logP energy  -7.18456

Hydropathy 



Literature Information


Title  Multiplicity of acidic subunit isoforms of crotoxin, the phospholipase A2 neurotoxin from Crotalus durissus terrificus venom, results from posttranslational modifications.

DOI  10.1021/bi00246a028,

Publication Year  1991

PubMed ID  1868083,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.