SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02634

Signal sequence   MPLRKMKIPFLLLFFLWEAES

Length  21

Organism  Homo sapiens (Human)

UniProt ID  P08842,

Motif  1..21



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  8EG3,

Predicted Structure ID  SPKB02634.cif

Structure  SPKB02634.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2610.25694

Aliphatic index  116.1904762

Isoelectric point  9.53484833

Charge (pH=7)   1.000941166

Topological polar surface area  852.3

Aromaticity  0.19047619

Average rotatable bonds  4

Number of hydrogen bond donors  29

Number of hydrogen bond acceptors  30

X logP energy  1.60467

Hydropathy 



Literature Information


Title  Characterization of rat and human steroid sulfatases.

DOI  10.1016/0167-4838(89)90187-8,

Publication Year  1989

PubMed ID  2765556,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.