SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02633

Signal sequence   MSEVPVARVWLVLLLLTVQVGVTAG

Length  25

Organism  Homo sapiens (Human)

UniProt ID  P08833,

Motif  1..25



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02633.cif

Structure  SPKB02633.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2651.24644

Aliphatic index  167.2

Isoelectric point  6.410149741

Charge (pH=7)   -0.000243889

Topological polar surface area  971.7

Aromaticity  0.04

Average rotatable bonds  3.32

Number of hydrogen bond donors  34

Number of hydrogen bond acceptors  33

X logP energy  -4.71063

Hydropathy 



Literature Information


Title  Identification of the amniotic fluid insulin-like growth factor binding protein-1 phosphorylation sites and propensity to proteolysis of the isoforms.

DOI  10.1111/j.1742-4658.2009.07318.x,

Publication Year  2009

PubMed ID  19765076,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.