SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02623

Signal sequence   MRGPSGALWLLLALRTVLG

Length  19

Organism  Homo sapiens (Human)

UniProt ID  P08582,

Motif  1..19



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  6XR0,

Predicted Structure ID  SPKB02623.cif

Structure  SPKB02623.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2024.49834

Aliphatic index  148.9473684

Isoelectric point  12.50010931

Charge (pH=7)   1.997977677

Topological polar surface area  758.38

Aromaticity  0.052631579

Average rotatable bonds  3.368421053

Number of hydrogen bond donors  28

Number of hydrogen bond acceptors  25

X logP energy  -4.12576

Hydropathy 



Literature Information


Title  A unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95/p97.

DOI  10.1084/jem.169.2.585,

Publication Year  1989

PubMed ID  2463331,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.