SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02622

Signal sequence   MARALCPLQALWLLEWVLLLLGPCAAPPAWA

Length  31

Organism  Homo sapiens (Human)

UniProt ID  P08514,

Motif  1..31



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  6V4P,

Predicted Structure ID  SPKB02622.cif

Structure  SPKB02622.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3388.19624

Aliphatic index  145.1612903

Isoelectric point  6.135737489

Charge (pH=7)   -0.124193321

Topological polar surface area  1090.82

Aromaticity  0.096774194

Average rotatable bonds  3.129032258

Number of hydrogen bond donors  38

Number of hydrogen bond acceptors  38

X logP energy  -0.01303

Hydropathy 



Literature Information


Title  Separation of important new platelet glycoproteins (GPIa, GPIc, GPIc*, GPIIa and GMP-140) by f.p.l.c. Characterization by monoclonal antibodies and gas-phase sequencing.

DOI  10.1042/bj2790419,

Publication Year  1991

PubMed ID  1953640,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.