SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02614

Signal sequence   MKIVLAIASLLALSAVYA

Length  18

Organism  Dermatophagoides pteronyssinus (European house dust mite)

UniProt ID  P08176,

Motif  1..18



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02614.cif

Structure  SPKB02614.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  1847.32994

Aliphatic index  190

Isoelectric point  9.298300651

Charge (pH=7)   0.996838851

Topological polar surface area  644.73

Aromaticity  0.055555556

Average rotatable bonds  3.333333333

Number of hydrogen bond donors  23

Number of hydrogen bond acceptors  24

X logP energy  -1.857

Hydropathy 



Literature Information


Title  The crystal structure of recombinant proDer p 1, a major house dust mite proteolytic allergen.

DOI  10.4049/jimmunol.175.6.3835,

Publication Year  2005

PubMed ID  16148130,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.