General Information
SPKB ID SPKB02586
Signal sequence MLGVLVLGALALAGLGFP
Length 18
Organism Homo sapiens (Human)
UniProt ID P07204,
Motif 1..18
Activity Information
Pathway SRP-dependent
Natural/Artificial Natural
Subcellular location ER
Secretion efficiency NA
Type Sec/SPI
Structure Information
PDB ID 7T4R,
Predicted Structure ID SPKB02586.cif
Physicochemical Information
Molecular weight 1712.16674
Aliphatic index 178.8888889
Isoelectric point 6.099999998
Charge (pH=7) -0.002015701
Topological polar surface area 549.23
Aromaticity 0.055555556
Average rotatable bonds 2.944444444
Number of hydrogen bond donors 18
Number of hydrogen bond acceptors 20
X logP energy -0.6842
Hydropathy 
Literature Information
Title Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation.
DOI 10.1002/j.1460-2075.1987.tb02448.x,
Publication Year 1987
PubMed ID 2820710,
Patent ID NA,
