SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02579

Signal sequence   MKLLQRGVALALLTTFTLASETALA

Length  25

Organism  Escherichia coli (strain K12)

UniProt ID  P07024,

Motif  1..25



Activity Information


Pathway  Sec

Natural/Artificial  Natural

Subcellular location  Periplasmic space

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  1USH,

Predicted Structure ID  SPKB02579.cif

Structure  SPKB02579.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2633.18514

Aliphatic index  140.8

Isoelectric point  9.695027686

Charge (pH=7)   0.999461077

Topological polar surface area  1031.18

Aromaticity  0.04

Average rotatable bonds  3.52

Number of hydrogen bond donors  37

Number of hydrogen bond acceptors  36

X logP energy  -8.22303

Hydropathy 



Literature Information


Title  Nucleotide sequence and transcriptional analysis of the E. coli ushA gene, encoding periplasmic UDP-sugar hydrolase (5'-nucleotidase): regulation of the ushA gene, and the signal sequence of its encoded protein product.

DOI  10.1093/nar/14.10.4325,

Publication Year  1986

PubMed ID  3012467,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.