SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02578

Signal sequence   MKVKVLSLLVPALLVAGAANA

Length  21

Organism  Escherichia coli (strain K12)

UniProt ID  P06996,

Motif  1..21



Activity Information


Pathway  Sec

Natural/Artificial  Natural

Subcellular location  Cell membrane

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  9A32,

Predicted Structure ID  SPKB02578.cif

Structure  SPKB02578.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2078.62804

Aliphatic index  171.9047619

Isoelectric point  10.80537956

Charge (pH=7)   1.997394232

Topological polar surface area  751.89

Aromaticity  0

Average rotatable bonds  3.238095238

Number of hydrogen bond donors  25

Number of hydrogen bond acceptors  27

X logP energy  -3.9353

Hydropathy 



Literature Information


Title  DNA sequence of the promoter region of the ompC gene and the amino acid sequence of the signal peptide of pro-OmpC protein of Escherichia coli.

DOI  10.1016/0014-5793(83)80364-0,

Publication Year  1983

PubMed ID  6297988,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.