SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02568

Signal sequence   MAFPPRRRLRLGPRGLPLLLSGLLLPLCRA

Length  30

Organism  Homo sapiens (Human)

UniProt ID  P06756,

Motif  1..30



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  7Y1T,

Predicted Structure ID  SPKB02568.cif

Structure  SPKB02568.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3354.21724

Aliphatic index  136.6666667

Isoelectric point  12.80106679

Charge (pH=7)   5.935989716

Topological polar surface area  1254.9

Aromaticity  0.033333333

Average rotatable bonds  3.5

Number of hydrogen bond donors  46

Number of hydrogen bond acceptors  40

X logP energy  -7.11898

Hydropathy 



Literature Information


Title  A novel vitronectin receptor integrin (alpha v beta x) is responsible for distinct adhesive properties of carcinoma cells.

DOI  10.1016/0092-8674(89)90172-4,

Publication Year  1989

PubMed ID  2467745,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.