SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02566

Signal sequence   MGPLMVLFCLLFLYPGLADS

Length  20

Organism  Homo sapiens (Human)

UniProt ID  P06681,

Motif  1..20



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02566.cif

Structure  SPKB02566.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2200.74024

Aliphatic index  136.5

Isoelectric point  3.749971056

Charge (pH=7)   -1.064394347

Topological polar surface area  676.4

Aromaticity  0.15

Average rotatable bonds  3.3

Number of hydrogen bond donors  23

Number of hydrogen bond acceptors  27

X logP energy  0.1739

Hydropathy 



Literature Information


Title  A Schistosoma protein, Sh-TOR, is a novel inhibitor of complement which binds human C2.

DOI  10.1016/s0014-5793(00)01304-1,

Publication Year  2000

PubMed ID  10734221,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.