SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02559

Signal sequence   MATGGRRGAAAAPLLVAVAALLLGAAG

Length  27

Organism  Homo sapiens (Human)

UniProt ID  P06213,

Motif  1..27



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  7PG0,

Predicted Structure ID  SPKB02559.cif

Structure  SPKB02559.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  2419.91434

Aliphatic index  130.7407407

Isoelectric point  12.50010931

Charge (pH=7)   1.997977677

Topological polar surface area  955.16

Aromaticity  0

Average rotatable bonds  2.814814815

Number of hydrogen bond donors  34

Number of hydrogen bond acceptors  32

X logP energy  -9.93176

Hydropathy 



Literature Information


Title  Substructural analysis of the insulin receptor by microsequence analyses of limited tryptic fragments isolated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis in the absence or presence of dithiothreitol.

DOI  NA,

Publication Year  1990

PubMed ID  2211730,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.