SPKB

Signal Peptide Knowledge Base

General Information


SPKB ID  SPKB02556

Signal sequence   MAMRAKGIRKNCQHLWRWGTMLLGMLMICSAAA

Length  33

Organism  Human immunodeficiency virus type 1 group M subtype B (isolate CDC-451) (HIV-1)

UniProt ID  P05879,

Motif  1..33



Activity Information


Pathway  SRP-dependent

Natural/Artificial  Natural

Subcellular location  ER

Secretion efficiency  NA

Type  Sec/SPI



Structure Information


PDB ID  NA,

Predicted Structure ID  SPKB02556.cif

Structure  SPKB02556.cif
Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)
Loading PAE…
Expected Position Error (Ångströms)


Physicochemical Information


Molecular weight  3750.65794

Aliphatic index  86.06060606

Isoelectric point  11.5518156

Charge (pH=7)   4.964343957

Topological polar surface area  1419.16

Aromaticity  0.060606061

Average rotatable bonds  3.848484848

Number of hydrogen bond donors  54

Number of hydrogen bond acceptors  51

X logP energy  -10.21709

Hydropathy 



Literature Information


Title  Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1.

DOI  10.1089/aid.1990.6.371,

Publication Year  1990

PubMed ID  2187500,

Patent ID  NA,



Faculty of Applied Sciences, Macao Polytechnic University, Macao, China.